PQQ Powder Pyrroloquinoline Quinone

PQQ Disodium Salt	PQQ Acid
CAS Number:	122628-50-6	72909-34-3
Molecular Weight:	374.17	330.21
Molecular Formula:	C14H4N2Na2O8	C14H2N2O8
Specifications:	99%	99%
Application:	Pyrroloquinoline quinone disodium salt is the more stable form of PQQ, which is more popular and can be used as a supplement and nutrition. More than 80% of health products on the market use PQQ disodium salt.

 

Intraduction:

Pyrroloquinoline quinone (henceforth PQQ) is a small quinone molecule which has the ability to be a REDOX agent, capable of reducing oxidants (an antioxidant effect) and then being recycled by glutathione back into an active form.
It appears to be quite stable as it can undergo several thousand cycles before being used up, and it is novel since it associates with protein structures inside the cell (some antioxidants,
mostly notably carotenoids like β-carotene and Astaxanthin, are located at specific areas of a cell where they exert proportionally more antioxidant effects due to proximity;
PQQ seems to do this near proteins like carotenoids do so at the cell membrane).

PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture.
It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.

Application:

It means Pyrroloquinoline Quinone may have the power to help protect brain function well into our advanced years. Initial evidence of this was demonstrated in a 2009 study published in the medical journal Food Style.
1 In this double-blind, placebo-controlled study, 71 men and women aged 45-65 consumed foods fortified with 20 mg of PQQ (as found in our new maximum potency formula),
Pyrroloquinoline Quinone plus CoQ10, or placebo, for 12 weeks. Throughout the study, subjects participated in cognitive tests designed to measure memory, recall and cerebral function.
The graph shown illustrates the results. Similar results were reported in a 2011 follow-up study in which Pyrroloquinoline Quinone was given directly as a supplement.

Function:
1.Improve the body’s immune function

As a necessary factor of human development, it can stimulate the growth of cells in the body, especially the activation of human B cells,
T cells, antibody production, improve the immune function of human body.Pyrroloquinoline Quinone is the most powerful bioactive substances so far.

2. Prevent and treat the liver damage

Can significantly reduce serum bilirubin, alanine aminotransferase levels, make liver function normal, regulate liver damage and have very good curative effect on liver disease.

3. Reduce free radical damage to human body

PQQ is a kind of oxidoreductase prosthetic group, involved in biological REDOX reaction in the body, can effectively remove free radicals in the body, reduce the harm of human body free radical, protect tissues, reduce the body damage caused by various diseases, such as heart disease, cancer and all kinds of inflammation.Free radicals is the source of diseases.

4. Regulate various neurological diseases

Pyrroloquinoline Quinone is a new kind of water-soluble vitamins, can promote the synthesis of neural factors in the human body, regulate various neurological diseases.

5. Promote the absorption of amino acids

Pyrroloquinoline Quinone is the prosthetic group of quinone protease, participate in the respiratory electron transport chain, in the human body through the effect of glucose, can promote the absorption of amino acids.Amino acid composition of cell SAP and synthetic protein peptide is the main raw material, is an important part of the body’s biological active substances.

6. Promote the synthesis of growth factors

Growth factor is the human growth hormone, stimulate biological growth, can stimulate human body cell growth, increase the cell density
Trace amounts of Pyrroloquinoline Quinone could improve the biological function of the organization’s ability to metabolize and growth.Why can slow the aging?

7.Prevent and treat the alzheimer’s disease

Pyrroloquinoline Quinone special biological activity and physiological function but also has the repair nerve fibers, the activation of neurons, activate the dormancy of the nerve cells,
can effective prevention and treatment of alzheimer’s disease and improve memory.Can effectively improve intelligence.

8.Promote the synthesis of glutathione

Glutathione by glutamic acid, cysteine and glycine combination of three peptides, has an important antioxidant effect, integrating detoxification,
harmful to the body poison into harmless substance, excreted in vitro, glutathione is bioactive enhancer.Pyrroloquinoline Quinone can promote the body’s glutathione synthesis, prevent and accumulation of hepatic bilirubin in cataract.

9.Strong anticancer function

1, the activation of NK cells for ANK, make its have kill tumor;

2, can make the NK cells and other immune cells gathered themselves together, and play a corps of operational capability, more effectively kill tumor cells;

3, closed tumor cells carrying iron protein receptors, blocking its function, inhibiting tumor growth and metastasis;

4, destroy the tumor cell lipid double, to dissolve tumor cell death;

5, prevent tumor cell DNA replication, and promote its apoptosis;

6, scavenging free radicals, prevent cancer, heart disease, etc.

COA
Item	Specification	Result
Physical & Chemical
Appearance	Fine Powder	Comforms
Color	Reddish orange to reddish brown	Conforms
Odor	Odorless	Conforms
Identification	IR Spectrum	Positive
Loss on Drying	≤12.0%	5.20%
Heavy Metals
Total Heavy Metals	≤10ppm	Conforms
As	≤1ppm	Conforms
Pb	≤0.5ppm	Conforms
Cd	≤0.1ppm	Comforms
Hg	≤0.1ppm	Conforms
Microbiological Tests
Total Plate Count	≤1000cfu/g	Conforms
Total Yeast & Mold	≤100cfu/g	Conforms
E.Coli	Negative	Negative
Salmonella	Negative	Negative
Staphylococcus	Negative	Negative