L Alpha GPC Alpha-Glycerophosphoryl Choline

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Product Name Choline glycerophosphate
CAS NO. 28319-77-9
Purity 99%
Melting point -98 C
Appearance and shape White powder
Product Name Glycerol Phosphatidyl Choline
Specification 98.5%~102.0%
Appearance Fine Powder with highly Hygroscopic
Mesh 80 mesh
Molecular formula C8H20NO6P
Molecular weight 257
CAS No 28319-77-9
Flow Chart It is mainly completed by alcohol extraction, extraction, chromatography, crystallization and other processes
Solubility Can be miscible with water, soluble in methanol, ethanol, insoluble in chloroform, ether, oil, etc

L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate, Glycerol Phosphatidyl Choline) is a naturalcholine compound found in the brain and in milk. It is also a parasympathomimeticacetylcholine precursor which may have potential for the treatment of Alzheimer’s disease and dementia. Alpha-GPC is also used as a nootropic dietary supplement to enhance memory and cognition.

It is a hydrolyzed product of phosphatidylcholine, the two fatty acyl groups of lecithin molecules. It is a water-soluble phospholipid precursor and neurotransmitter that naturally exists in the human body. It is also a unique cell protective agent that can support the fluidity and integrity of cell membranes. Years of experimental research and clinical application have shown that GPC can not only improve people’s memory and cognitive ability, but also have significant effect on brain circulation decline and Alzheimer’s disease, so it is called the anti-aging nutrient of brain. In addition, it can also resist muscle atrophy, protect blood vessels and other effects. Therefore, GPC is of great value in both the healthcare and pharmaceutical industries.


1.Glycine phosphatidylcholine is a naturally occurring intermediate of phospholipid metabolism in the human body. It exists in cells and pervasives the human body and is structurally composed of choline, glycerol and phosphoric acid. It is a major preservation form of choline and is recognized as the source of choline. Because belongs to the endogenous substance so the toxic side effect is very low. After absorption, glycine phosphocholine is decomposed into choline and glycerol phospholipid under the action of enzymes in the body: choline participates in the biosynthesis of acetylcholine, which is a kind of neurotriggering transmitter; Glycerol phosphate lipid is the precursor of lecithin and is involved in the synthesis of lecithin. The main pharmacological effects include protecting the metabolism of choline, ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, and improving blood circulation; Improved cognitive and behavioral responses in patients with capillar nerve trauma.

2.Choline phosphoglycerol is not only one of the main osmotic substances in renal medulla cells, but also can change the concentration of osmotic substances inside and outside the cell in parallel. This is good for cerebrovascular health, especially for behavioral and emotional disorders caused by brain decline. Choline phosphoglycerol has the potential to treat and prevent a variety of biochemical diseases. Researchers have found that it can alter the structure of phosphate lipids in neuronal membranes, and it has the curious effect of reducing physical tension in a factor associated with neural-tissue degeneration syndrome.

3. Health care products:

L-α-phosphocholine has been recognized as GRAS (generally recognized as Safe Substance) by FDA in the United States in 2012. Currently, L-α-phosphocholine is widely used in dietary supplements, food supplements and nutritional foods in the United States, Canada, Japan, the Netherlands, the United Kingdom and other countries. According to the available evidence, dietary GPC supplementation is beneficial to: 1. Training and maintenance of concentration, attention, and memory; 2. 2. Speed and overall clarity of thought processing; 3. Emotions, including positive attitudes and social skills; 4. Recovery of brain function after circulatory deprivation; 5. Recovery of declining mental function; 6. Skeletal muscle integrity, including growth and regeneration; 7. Kidney and liver function, including renewal and detoxification; 8. Fertility, including sperm performance and fertilization ability; This product has more than 10 years of edible history, because of its safety and effectiveness, by the majority of consumers love.

4. Medicines:

L-α-glycine has been indicated primarily as a drug in patients with a 10-day ischemic attack (stroke or transient ischemic attack), mild-to-moderate Alzheimer’s dementia, and multiple cerebral infarct dementia. It’s also a liver tonic and a prescription drug for Alzheimer’s. Different countries report different indications, such as South Korea: Alzheimer’s disease, memory loss, depression; Cerebral ischemic stroke treatment, Alzheimer’s disease and memory loss in Russia; Vietnam: Post-stroke rehabilitation, craniocerebral trauma, trauma recovery, Alzheimer’s disease, confusion, memory loss in the elderly.

5. More strength from work-outs and training programs
Acts as a precursor of acetylcholine (ACh); thus, Alpha-GPC activates cholinergic transmission which permits the development of more strength from work-outs and training programs, plus reducing levels of somatostatin in the hypothalamic-pituitary axis;

6. Improved lipotrophic functions in the liver
Elevations in blood and tissue levels of the essential nutrient, choline, which supports improved lipotrophic functions (methyl group transferases) in the liver. Research has shown that fatty liver, a condition associated with obesity, diabetes and heavy alcohol consumption, often leads to cirrhosis of the liver or liver failure. Studies conducted by Alan L. Buchman, M.D., associate professor of medicine at The Feinberg School of Medicine at Northwestern University, have shown that fatty liver can be prevented and possibly even eliminated with increased levels of choline. Alpha-GPC also acts synergistically with the body’s store (and/or supplementation) of S-adenosyl-L-methionine (SAM or SAMe) and folic acid, vitamin B12 and vitamin B6 to facilitate methyl group transfers in the brain and liver;

7. Improved balanced and coordination
Produces improved balanced and coordination when combined with ‘skill set’ practice and training as a result of normalized nerve transmission in the brain, and in cardiac, skeletal and smooth muscles.

Widely used in dietary supplements, food supplements and nutritional foods as well as medicines main dosage forms injection, capsule, oral liquid.

Product Application

1,Alpha GPC is a chemical released when a fatty acid found in soy and other plants breaks down.

 2,It is used as medicine. In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. 

 3,In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.

 4,Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA). Alpha-GPC is also used for improving memory, thinking skills, and learning.


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